Aging-related declines in the neuromuscular system (muscle mass, strength, and physical function) have been hypothesized to occur as a result of oxidative stress, particularly in post-menopausal women, with subsequent damage to DNA. University of Valencia researchers in Spain investigated the effects of a 16-week TheraBand resistance exercise program at different intensities. Healthy older females were randomly assigned to a high-intensity (85% 1RM x 6 reps) or moderate intensity (70% 1RM x 15 reps). They used the TheraBand OMNI Scale to regulate intensity. Both groups performed the following exercises: upright row, incline row, elbow curl, narrow stance squat, lunge, and hip abduction.
Both exercise groups showed significant improvement sin physical function with no significant difference between groups; however, the moderate intensity group had more beneficial changes in biomarkers of oxidative stress and DNA damage. The authors noted that performing high-intensity resistance exercise may significantly increase oxidative stress, and recommended moderate-intensity exercise with elastic resistance in older women.
Gargallo P, et al. The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women. Biol Res Nurs. 2018 Mar;20(2):205-217.
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